Prevalence and predictive factors of transient and permanent congenital hypothyroidism in Fars province, Iran

Abstract Introduction There is no data on the number as well prevalence of congenital hypothyroidism (CH) in Fars province. Hence, we designed this study to analyze latest and possible predictive factors transient permanent CH Method This cross sectional based province screening from 2013 2016. A total 294,214 newborns were screened with 938 confirmed cases CH, which included study. After recall completion missing data, follow-up for 642 thyroid stimulating hormone (TSH) concentrations levothyroxine doses ten outpatient visits final vs. diagnosis included. Results The incidence rate was 1:313.66, out cases, 66.04 % had while 33.96 CH. TSH level trend during not statistically different between two groups ( P = 0.312). cutoff point > 2.25 µg/kg (sensitivity: 76.11 %, specificity: 58.52 %) at third year a concentration 43.35 mIU/L venous sampling (initial TSH) 31.66 90.32 Conclusion has one highest Iran. Levothyroxine dose 3rd 1st sample are Iranian population; however, follow ups unreliable predictors.